Methamphetamine-induced neurotoxicity disrupts naturally occurring phasic dopamine signaling
نویسندگان
چکیده
منابع مشابه
Microglial activation precedes dopamine terminal pathology in methamphetamine-induced neurotoxicity.
Previous studies have demonstrated methamphetamine (METH)-induced toxicity to dopaminergic and serotonergic axons in rat striatum. Although several studies have identified the nature of reactive astrogliosis in this lesion model, the response of microglia has not been examined in detail. In this investigation, we characterized the temporal relationship of reactive microgliosis to neuropathologi...
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Methamphetamine (Meth) is an addictive psychostimulant widely abused around the world. The chronic use of Meth produces neurotoxicity featured by dopaminergic terminal damage and microgliosis, resulting in serious neurological and behavioral consequences. Ample evidence indicate that Meth causes microglial activation and resultant secretion of pro-inflammatory molecules leading to neural injury...
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Three different approaches were employed to assess various markers associated with sex differences in responses to methamphetamine (MA). Bioassay measures reveal that MA treatment results in significantly greater reductions in body weight and increases in body temperature in male mice. Protein and mRNA determinations show significant increases in Bcl-2 and PAI-1 in male mice, while females show...
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ژورنال
عنوان ژورنال: European Journal of Neuroscience
سال: 2013
ISSN: 0953-816X
DOI: 10.1111/ejn.12209